John J. Pacifico is a General Partner, Chief Operating Officer, and Chief Financial Officer at Canaan Partners. See sector focus and contact routes.
John J. Pacifico is a General Partner, Chief Operating Officer, and Chief Financial Officer at Canaan Partners, where he has worked since 2000 with nearly 25 years of venture capital experience and previously served as CEO of two healthcare companies. His investment focus centers on early-stage companies in enterprise software, fintech, and infrastructure, though he initially joined Canaan as a healthcare investor and continues to hold board seats in healthcare firms like Abyrx and Transposon Therapeutics. While specific check sizes and lead/follow behavior are not publicly detailed, Pacifico helped raise over $1.75 billion for Canaan’s early-stage technology and healthcare funds, indicating substantial capital deployment capacity. Notable portfolio companies where he serves on the board include Abyrx (a biosurgical firm), Aceiss, Axcelius, and Transposon Therapeutics, alongside his co-founded SaaS company Kairuku for medical enterprises. Pacifico’s distinctive perspective stems from his dual role as an investor and operator, having launched biosurgical companies from the investor side and invented FDA-cleared medical products himself. No public writing
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