645 Ventures is an early-stage venture capital firm founded in 2013 by Aaron Holiday and Nnamdi Okike. See sector focus and contact routes.
645 Ventures is an early-stage venture capital firm founded in 2013 by Aaron Holiday and Nnamdi Okike, based in New York City and San Francisco with over $550 million in assets under management. The firm invests primarily in Seed, Series A, and Series B rounds across enterprise software, SaaS, developer tools, fintech, healthcare, and commerce, with a geographic focus on North America. Typical check sizes range from $1 million to $20 million, and the firm often acts as a lead or co-lead investor. Notable portfolio companies include RentSpree, Aryeo, Efficient Capital Labs, AppLovin, JUUL, and Calm. A distinctive aspect of 645 Ventures is its data-driven approach powered by a proprietary software platform called Voyager, which it uses to identify high-potential startups through thematic research and metrics. The firm emphasizes four founder paradigms—purity of motivation, earned secret, obsessed problem solving, and non-consensus thinking—as part of its research-driven investment philosophy.
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