Lee Shapiro is the Managing Partner and co-founder of 7wire Ventures. See sector focus and contact routes.
Lee Shapiro is the Managing Partner and co-founder of 7wire Ventures, a Chicago-based venture capital firm he established over a decade ago with serial entrepreneur Glen Tullman. The firm’s investment thesis targets early-stage digital health companies, specifically focusing on seed and Series A rounds that create “Informed Connected Health Consumers” through technology-driven healthcare solutions. 7wire Ventures typically seeks investments that deliver at least two to three times return on investment to buyers, though specific check sizes and lead/follow behavior are not explicitly detailed in available sources. Notable portfolio companies include Livongo Health, where Shapiro previously served as CFO and led its IPO, as well as Click Therapeutics, Clover Health, and Homethrive, for which he holds board memberships. Shapiro’s distinctive point of view centers on tackling healthcare’s fundamental challenges through connected consumer health, a theme he has discussed in public interviews regarding the future of digital health. His personal angel investing activity includes a 2024 investment in RadiantGraph, an enterprise healthcare systems company.
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