Lynne Chou O’Keefe is the Founder and Managing Partner of Define Ventures. See sector focus and contact routes.
Lynne Chou O’Keefe is the Founder and Managing Partner of Define Ventures, one of the largest early-stage health tech firms with $800 million in assets under management. She previously served as a Senior Partner at Kleiner Perkins focused on digital health and connected devices before launching Define in 2020 with an initial $87 million fund. Define Ventures invests in early-stage digital health companies across incubation, seed, Series A, and Series B stages, primarily in the Silicon Valley region. The firm has backed approximately 24 companies to date, including notable portfolio members Hims & Hers, Livongo, and Evolent, which have generated $23 billion in combined exit value. Chou O’Keefe sits on the publicly traded board of Hims & Hers and emphasizes a high-conviction approach to scaling category-defining health tech companies. She has been recognized as WSJ’s Women in Venture Capital to Watch and Rock Health’s Top 50 ICON honoree, reflecting her influence in digital health investing.
StartupFundraising tracks this investor record from SEC filings and announced rounds, updating focus, location and portfolio history as new data lands. Use it to gauge fit before an outreach, then widen the search to investors in San Francisco.
Investors like Lynne Chou · Full investor directory · Investor access · Company funding database