David Crean, Managing Partner at Cardiff Advisory, Cardiff By The Sea, California. See sector focus and contact routes.
David H. Crean, Ph.D., is the founder and managing partner of Cardiff Advisory, a boutique life sciences M&A and strategic advisory firm, and previously served as a General Partner at 1004 Venture Partners with over 30 years in life sciences and healthcare investing. His investment focus centers on biotechnology, healthcare technology, and enterprise software, targeting early-stage to growth-stage companies with disruptive technologies and strong intellectual property. While specific check sizes and lead/follow behavior for Cardiff Advisory are not publicly documented, his prior venture role emphasized strategic guidance to help high-growth companies scale. Notable portfolio affiliations include his role as Chief Business Officer at MediciNova, independent director at Cenna Biosciences, and board chair of Paracrine, reflecting deep involvement in biopharma and diagnostics. Crean’s distinctive point of view is shaped by his personal connection to Alzheimer’s disease, which drives his focus on diagnostic and therapeutic advances in that area. He has publicly discussed geopolitical tensions threatening the life sciences investment climate while highligh
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