Rob Ness is the General Partner and sole founder of Asymmetry Ventures. See sector focus and contact routes.
Rob Ness is the General Partner and sole founder of Asymmetry Ventures, a seed-stage venture capital firm in San Francisco he established in 2018 after spending seven years as an AngelList syndicate lead deploying over $40 million across 200+ angel investments. His investment thesis focuses on seed-stage companies that “push humanity forward,” with particular emphasis on deep tech sectors including biotechnology, AI drug discovery, quantum computing, advanced materials, and space technology. The firm typically deploys initial checks between $100,000 and $500,000, with capacity to invest up to $25 million per company, and Ness often leads rounds given his firm’s seed-stage focus. Notable portfolio companies include BillionToOne, Foresight Mental Health, Mast Reforestation (formerly DroneSeed), and Orbit Fab. Ness distinguishes his approach by seeking defensible businesses with natural barriers to entry, recurring revenue, and founding teams that have already demonstrated tangible progress. He has not published public writing, but his stated point of view centers on backing “civilization-level impact” startups with a “sci-fi flavor” in deep tech.
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