James Topper, General Partner at Frazier Healthcare Partners, Menlo Park, California. See sector focus and contact routes.
James N. Topper is a Managing Partner and co-founder of Frazier Healthcare Partners who invests primarily in life sciences and biopharmaceuticals, focusing on early-stage venture opportunities from seed through Series A and B, as well as company creation. His typical check size ranges from $5 million to $10 million upfront, with total commitments of $15 million to $25 million per company over its lifecycle. Notable portfolio companies he has led include Acerta Pharma (sold to AstraZeneca), Calistoga Pharmaceuticals (sold to Gilead), Portola, and Threshold, with many achieving IPOs or major acquisitions. Topper’s distinctive thesis emphasizes novel therapeutics across the full drug development spectrum, from preclinical to commercialization, and actively creates one to two companies per year.
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