James Topper, General Partner at Frazier Healthcare Partners, Menlo Park, California. See sector focus and contact routes.
James N. Topper is a Managing Partner and co-founder of Frazier Healthcare Partners who invests primarily in **life sciences** and **biopharmaceuticals**, focusing on **early-stage venture** opportunities from seed through Series A and B, as well as company creation [1][2][5]. His typical check size ranges from **$5 million to $10 million** upfront, with total commitments of **$15 million to $25 million** per company over its lifecycle [4]. Notable portfolio companies he has led include **Acerta Pharma** (sold to AstraZeneca), **Calistoga Pharmaceuticals** (sold to Gilead), **Portola**, and **Threshold**, with many achieving IPOs or major acquisitions [2][4]. Topper’s distinctive thesis emphasizes **novel therapeutics** across the full drug development spectrum, from preclinical to commercialization, and actively **creates one to two companies per year** [4][5][8].
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