John Freund is the Founder and Managing Director of Skyline Ventures. See sector focus and contact routes.
John Freund is the Founder and Managing Director of Skyline Ventures, a Palo Alto-based healthcare venture capital firm he established in 1997 alongside Eric M. Gordon after coming from medical and healthcare operating backgrounds. The firm invests exclusively in human healthcare, targeting early-stage therapeutics, medical devices, diagnostics, and digital health companies within the United States. Skyline typically leads investment rounds, deploying $15 million to $25 million of total capital per portfolio company across multiple rounds, with initial checks ranging from $10 million to $15 million. Notable portfolio companies include AcelRx Pharmaceuticals, Crescendo Bioscience, NovaCardia, and Pionyr Immunotherapeutics, in which Freund personally invested as an angel investor. The firm’s distinctive point of view centers on its team of professionals holding MD or PhD degrees who specialize in small molecule and protein therapeutics, applying explicit check-sizing discipline to its investments. Freund has not published public writing or a distinctive published thesis separate from the firm’s stated focus on product-focused healthcare companies.
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