John Spinale is the Co-Founder and Managing Partner (often cited as General Partner) of Jazz Venture Partners. See sector focus and contact routes.
John Spinale is the Co-Founder and Managing Partner (often cited as General Partner) of Jazz Venture Partners, a San Francisco-based venture capital firm he launched in 2015 after spending over 25 years as a consumer technology operator building five companies through acquisition. His investment thesis targets early-stage companies at the intersection of artificial intelligence, neuroscience, and human performance, focusing specifically on seed and Series A rounds in sectors like brain health, mental wellness, and longevity. The firm’s typical check size ranges from $100,000 to $5.0 million with a sweet spot around $1.5 million, and Spinale has served as the lead partner on 22 deals. Notable portfolio companies in his track record include Sounding Board, Pymetrics, Akili Interactive, and Outside, with Pymetrics being acquired in 2022 and Akili going public. Spinale distinguishes himself by leveraging his operational background in gaming and media to apply game-delivery mechanisms toward health, learning, and training applications rather than pursuing broad tech trends. He currently sits on the boards of several portfolio firms, including Ak
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